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We demonstrate a discrete chemical release method, capable of delivering picoliter volumes of chemical solutions with 100 µm of spatial resolution and 20 µs of response time. The releasing mechanism is based on the transfer of pulsed liquid plugs through a hydrophobic air chamber. A microfluidic chip consisting of such a releasing array (2 × 10) is designed and fabricated. Numerical simulation and experimental testing are performed to verify the working principle. Advantages of this release-on-demand technology include leakage-free, fast response and versatile control of release profile. This new method could be a key enabling technology for precisely controlled release of biochemicals for modern pharmacological and biological research.[ 2006-0253]Index Terms-Air gap, discrete chemical stimulation, microfluidic chip, picoliter chemical release, pulsed liquid ejection.

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