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variants were found mostly as pure variants. With a median follow up of 6.5 years, patients who harbored pure variant were found at multivariablean alyses with lower survival outcomes when compared with pure urothelial carcinoma (all p<0.01). Conversely no differences were found between mixed variant vs. pure urothelial at multivariable Cox regression analyses predicting recurrence, CSM and OM (all p>0.1).CONCLUSIONS: Presence of histologic variants at RC is a common finding accounting for approximately 30% of specimens. In this setting, the presence of a pure variant but not the presence of mixed variant with urothelial carcinoma is related to a detrimental effect on survival outcomes after RC.

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RESUMENADENOCARCINOMA VESICAL PRIMARIO: NUESTRA EXPERIENCIA El adenocarcinoma vesical es un tumor infrecuente. Se clasifica según su origen en: primario, secundario y uracales. Generalmente se caracteriza por crecer hacia el espesor de la pared provocando manifestaciones clínicas tardías, esto demora el diagnóstico y así, pese a tratamiento agresivo, suele tener muy mal pronóstico.Existen pocas series amplias publicadas por lo que no están establecidas claras pautas de actuación con este tipo de tumores. Presentamos los once casos de adenocarcinoma vesical primario en nuestro centro entre el año 1986 y el 2003 y revisamos la bibliografía.Palabras clave: Adenocarcinoma. Vejiga. Uraco. Cistectomía. ABSTRACTPRIMARY ADENOCARCINOMA OF THE URINARY BLADDER:OUR EXPERIENCE Adenocarcinoma of the bladder is an uncommon neoplasm. Depending on its origin it is classified in: primary, secondary and urachal. Generally it grows to the density of the wall, so its clinical aparience is delayed, with the subsequent delayed diagnosis and although an agressive treatment is performed, it frequently has a very bad prognosis.Since there are very few publications of this kind of neoplasm in the literature the lines of actuation in this pathology are not well established.We report the eleven cases of adenocarcinoma neoplasm of the bladder treated in our centre and review the literature. ORIGINALEl adenocarcinoma vesical es un tumor muy poco frecuente caracterizado por su diagnóstico tardío, tratamiento agresivo y pronóstico sombrío. Se clasifican en primarios, de uraco y metastásicos siendo estos últimos los más frecuentes. Existen pocas series amplias publicadas no estando claramente estandarizados los criterios de actuación. Se describe nuestra serie y se revisa la literatura publicada.

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