INTRODUCTION
It is worth distinguishing between the two strategies of expectant management for PCa. WW entails administering non-curative androgen deprivation therapy to patients upon development of symptomatic progression, whereas AS entails delivering curative treatment upon signs of disease progression. The objectives of the two management strategies and the patients enrolled in either are different.
AIM
To review the role of AS as a management strategy for patients with low-risk PCa and review the benefits and pitfalls of AS.
METHODS
We performed a systematic review of AS for PCa in the literature using the National Center for Biotechnology Information's electronic database PubMed. We conducted a search in English using the terms: active surveillance, prostate cancer, watchful waiting, and conservative management. Selected studies were required to have a comprehensive description of the demographic and disease characteristics of the patients at the time of diagnosis, inclusion criteria for surveillance, and a protocol for the patients’ follow-up. Review articles were included but not multiple papers from the same datasets.
CONCLUSIONS
AS appears to reduce overtreatment in patients with low-risk PCa without compromising cancer-specific survival at 10 years. Therefore AS is an option for select patients who want to avoid the side effects inherent to the different types of immediate treatment. However, inclusion criteria for AS and the most appropriate method of monitoring patients on AS have not yet been standardized.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.