No abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

A novel bis benzoxazin-4-one derivative has been synthesized and utilized to construct a new series of bis quinazolin-4(3H)-one derivatives via the reactions with different nitrogen nucleophiles namely, primary amines (ammonia, ethanolamine, and 4-aminoantipyrine), secondary amines (morpholine and piperidine), diamine (o-phenylenediamine), hydrazine hydrate, and hydroxylamine. The insecticidal efficacy of newly synthesized compounds was also studied. The structural features of the synthesized compounds were assigned by spectral analysis.

In this work, new chitosan-based Schiff bases were synthesized by the reaction of chitosan with quinolinone and pyranoquinolinone giving CSQ, and CSP, respectively. The novel Chitosan Schiff bases were grafted on silver nanoparticles providing CSQ/Ag, CSP/Ag structures. Characterization of isolated compounds was carried out by FT-IR, TGA, XRD, SEM, and TEM. The target compounds CSQ, CSP, CSQ/Ag, and CSP/Ag were evaluated as antitumor agents against three cancer cell lines, liver (HepG-2), colon (HCT-116), and breast (MCF-7). Compound CSQ/Ag disclosed potent cytotoxic effect with IC50 values in the range of 41.9–55.1 μg/ml in comparison with 5-fluorouracil against different cancer cell lines. Besides, the antioxidant activity of chitosan and its quinolinone and pyranoquinolinone analogues was assessed as radical scavengers versus 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH%). The compound CSQ/Ag emerged as the most active member in scavenging the DPPH radicals. The obtained findings proved that the new Schiff bases/silver nanoparticles of chitosan showed higher antiproliferative and antioxidant activities than the blank CS and would be highly applicable in biomedical fields. Graphical abstract