A quantitative and qualitative study of the seasonal var iation of free flavone aglycones from Sideritis leucantha (Lamiaceae) has been carried out by means of HPLC. The flavonoid pattern remained unvariable with seasonal varia tion supporting flavonoid aglycones as idoneous taxonomic markers. Quantitative variations were observed, being the summer months which yielded a higher content in these compounds. These highly methylated flavone aglycones are located in the leaves surface as part of the excretion mate rial.
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