Previous research suggested a positive relationship between levels of serum estrogen and seizures, a negative relationship between levels of serum Ca++ and seizures, and a negative relationship between serum levels of estrogen and Ca++. This study sought a relationship between levels of serum estrogen, ionized calcium, progesterone, and its possible effect on seizures during the menstrual cycle of epileptic women. The negative relationship between serum estrogen and Ca++ was confirmed. However, a study of 15 institutionalized epileptic women, all with a diagnosis of primary generalized epilepsy, demonstrated that fewer seizures occurred in midcycle (when estrogen levels were elevated and Ca++ levels were decreased) than at other stages of the menstrual cycle. This is suggestive of a protective (anticonvulsant) aspect of the hypothalamo-hypophyseal negative feedback system, previously unreported.

This study was conducted to determine whether indoor air pollution factors affected respiratory function and symptoms in 1357 non-smoking Caucasian children. Interviews were conducted to determine: exposure to pets and to gases, vapours and dusts from hobbies; the use of gas stoves; fireplaces, air conditioners and humidifiers; type of heating systems; and the number of residents, and the number of smokers in the home. The forced expiratory volume in one second (FEV1) was obtained from maximum expiratory flow volume curves, and symptoms from the application of a standardized questionnaire. Indoor pets and the use of fireplaces and humidifiers had no consistent relationships with FEV1 when considered individually or in combination with the other factors. Hobbies, the use of gas stoves, the absence of air conditioning, the use of hot water heating, crowded homes, and the presence of smokers in the home all had negative relationships with FEV1. The largest effect on lung function was observed in children from homes with hot water heating systems, whereas the smallest effect was observed in children with smokers in the home. Children who lived in homes with hot water heating systems with no air conditioning had mean FEV1 of up to 0.4 litres lower than did their counterparts who lived in homes with forced air heating and air conditioning. Pets, heating systems, cooking fuel, crowding and passive smoking showed no consistent effects on the reporting of any of the symptoms. Girls who were exposed to the emissions from indoor hobbies reported more phlegm, wheeze and dyspnoea.

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