Bone metastases are common in advanced cancer, occurring up to 75% of patients with advanced breast cancer. Complications of bone metastases include bone pain, hypercalcemia and skeletal-related events (SERs), such as fracture, need for radiation or surgery to bone, or spinal cord compression. A 50 year-old patient with advanced breast cancer, who has multiple skeletal-related events and poorer overall quality of life.
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