No abstract

No abstract

Amberlite IR-12O(H) ion-exchange resin (0-5 g., dried) was added to a mixture of redistilled 2 : 3-dihydropyran (17 g.) and ethyl glycollate (10 g.). The temperature rose slowly from 22" to 26". The mixture was kept for 20 hr. at room temperature, then filtered, and the filtrate was distilled as before.The amide was prepared by treatment of the ester with an excess of ammonia solution (d 04380) overnight. It crystallised after removal of solvent under reduced pressure and recrystallised from benzene as prisms, m.

Compounds possessing certain structural features of both laudexium and suxamethonium have been synthesised in an attempt to obtain a short-acting true curarising agent. The action of several of these compounds is antagonised by neostigmine ; whilst, however, some are short-acting as expected, others are long-acting. The alkylation of tetrahydropapaverine has been investigated.THE muscle relaxant suxamethonium (I) is very short-acting because of its ready enzymic hydrolysis to the comparatively inactive choline hydrogen succinate ; consequently it has proved to be of considerable value in anzsthesia, although the lack of a satisfactory antagonist is a disadvantage. Moreover, since the initial observation by Churchill-Davidson 2 of the post-operative muscle pains and stiffness which occasionally follow its use, growing concern for these factors has been expressed by several groups of worker^.^ Laudexium (11) is antagonised by neostigmine, but has a duration of action greater than + Me, N . [CHJ ,.O-CO .[CHd ,.CO-OfCHq ,*NMe 2c1-Y = OM e (17) Y*[CHJ 2.NH.CO*[CHJn-C0.NH-[CH~,.Y 2X-that of suxamethonium; however, so far as is known, it does not cause muscle pains or stiffness. It therefore appeared possible that by incorporating certain of the chemical features of both laudexium and suxamethonium into one molecule, some of the products

No abstract