Clinical RelevanceDespite oxalate desensitizer showing a decrease in the rate of resin-dentin bond degradation over time, it compromised the baseline bond strength of etch-and-rinse adhesives to dentin. Further investigation regarding reliability of the combination of oxalate desensitizers and etch-and-rinse adhesives is required prior to implementation of this approach in the clinical routine. SUMMARYPotassium oxalate desensitizers were previously shown to effectively reduce the immediate permeability of resin-bonded dentin. The current study evaluated whether the effect of the combined application of oxalate with etch-and-rinse adhesives interferes with the durability of resindentin bonds when using etch-and-rinse adhesives. The bond strength of resin-bonded dentin specimens composed of two-step or three-step etch-and-rinse adhesives (Single Bond, One-Step and Scotchbond Multi-Purpose, respectively) BISCO, Inc). The treatment of dentin with potassium oxalate was shown to negatively affect the baseline bond strength of resin-bonded dentin specimens, regardless of the adhesive used (p<0.05). After storage, the bond strength of the resin-bonded interfaces was significantly reduced for all the tested groups (p<0.001). Nevertheless, the rate of decreasing bond strength was significantly lower for oxalatetreated specimens than for the controls (p<0.05).