J Montague-Clouse scite author profile

Adverse drug reactions among elderly patients pose a significant clinical problem. The authors used a serum radioreceptor assay [RRA] to quantify drug-induced muscarinic blockade in 34 randomly selected nursing home residents. A random intervention group and the nonintervention control subjects were then retested 4 weeks later. The reduction of serum antimuscarinic activity (as determined by RRA) did relate to changes on several measures of cognitive function. A calculated "antimuscarinic index" lost significance with the RRA following intervention and may have overestimated the impact of a dosage reduction.

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Buspirone: Effects on Prolactin and Growth Hormone as a Function of Drug Level in Generalized Anxiety

Tollefson

Godes

Montague-Clouse

et al. 1989

Journal of Clinical Psychopharmacology

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Treatment of Comorbid Deneralized Anxiety in a Recently Detoxified Alcoholic Population with a Selective Serotonergie Drug (Buspirone)

Tollefson¹,

Montague-Clouse²,

Tollefson³

1992

Current Opinion in Cardiology

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