The first case of a pure primary yolk-sac tumor of the lung is presented. The tumor developed in the right upper lobe of a 31-year-old man; preoperatively, the serum alpha-fetoprotein concentration was elevated. Treatment consisted of pulmonary segmentectomy with postoperative combination chemotherapy. The patient is alive and well 13 months after surgery with a normal serum alpha-fetoprotein concentration.

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It has been previously shown that activated alveolar macrophage in idiopathic interstitial pneumonia (IIP) played an important role in the process of fibrosing, but the initial agent which activates alveolar macrophages has not been proved. The present study was designed to make quantitative analyses of trace elements in the lung tissue speciments of IIP patients and normal controls. Particle induced X-ray emission (PIXE) was used. The IIP group consisted of 11 patients and the Control group, which had no apparent history for dust inhalation and lung diseases, consisted of 9 subjects. More silicon and magnesium were found in the IIP group than in the normal controls. These data suggested that inhalation of silicon and magnesium might be one of the etiologic factors of IIP.