No abstract

Various new substituted formazans were synthesized and characterized by elemental analyses, IR and mass spectral data. The compounds were evaluated for their ability to protect against inflammation by carrageenin-induced paw edema in albino rats of either sex. The active derivatives of the present series were also tested for their analgesic activity against aconitine-induced writhing in albino mice and ulcerogenic activity in albino rats. The toxicity of the compounds was assessed by determination of their approximate LD₅₀ on albino mice. An attempt has also been made to establish a structure-activity relationship.

Eleven Mannich bases (cf.

Fifteen new 3‐arylaminomethyl‐5‐(2‐hydroxy‐3,5‐dibromophenyl)‐1,3,4‐oxadiazole‐2‐thiones were synthesized and characterized by their sharp melting points, elemental analyses and ir spectra. These substituted oxadiazolylthiones were evaluated for their enzyme inhibitory activity. All compounds inhibited in vitro monoamine oxidase and succinate dehydrogenase activity of rat brain homogenates. The degree of monoamine oxidase inhibition ranged from 59‐93% at a final concentration of 1 × 10−4 M whereas the inhibition of succinate dehydrogenase was 49‐100% at a final concentration of 5 × 10−5 M.