1395Controlled trial of cysteamine and dimercaprol after paracetamol overdose Clinical studies indicate that compounds containing a sulphydryl group protect against paracetamol-induced hepatic necrosis,' 2 but there are few data on their relative efficacy. We report the results of the first controlled clinical trial comparing two such compoundsnamely, cysteamine (mercaptamine) and dimercaprol. Patients, methods, and resultsAll 52 patients (34 women, 18 men) were seen within 10 hours after paracetamol overdose. Plasma paracetamol concentrations, measured by a rapid ether extraction method, fell above a line on a semilogarithmic graph

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