Objective Sylvian fissure operculization (SFO) is a dynamic process throughout gestation and is

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Oral poster abstractsDoppler. The 24 patients in our series consisted of 17 MCDA twins (7 with TTTs, 5 with Fetal anomaly, 4 with TRAP sequence and 1 with severe IUGR) 1 set of MCTA Triplets, 4 sets of DCTA Triplets(2 with TTTS and 2 multi fetal reductions), 1 set of DCDA Triplets and 1 MCMA Twins. Gestational age at the time of the procedure ranged between 13 + 0 weeks and 27 + 4 weeks (median -18 + 1 weeks). Results: The procedure was technically successful in 100% of cases. MRI of the surviving fetuses was normal in all the cases. 1 case miscarried, 12 have delivered and 11 pregnancies are ongoing with no complications seen on follow up scans. There were no maternal complications due to the procedure. Conclusions: Radiofrequency ablation is a safe and effective procedure for fetal reduction in complicated monochorionic pregnancies. OP09.06 Late terminations of pregnancy -indications for fetocide in a multi ethnic population in the UKO. B. Navti, A. Opoku, J. Konje, M. Khare Women's and Perinatal Services, University Hospitals of Leicester NHS Trust, Leicester, United KingdomFollowing identification of major anomalies on ultrasound, termination of pregnancy may be an option. In the UK, when the diagnosis is made after 21 weeks gestation and the condition is not lethal, fetocide is recommended as part of the medical termination. Aim: Review the indications and gestations for fetocides at a teaching hospital between Jan 2002 and December 2008. Method: We serve a multiethnic population with strong cultural and religious beliefs in relation to termination of pregnancy. Fetocide is offered as an option for all late terminations of pregnancy after 21 weeks of gestation. This was a retrospective review of all cases where a fetocide was performed in our hospital over six years. The obstetric database was reviewed for maternal demographics, indication and gestational age at fetocide, karyotyping and postmortems. Results: During the 6 years there were 62 fetocides performed at a mean gestational age of 23 weeks (range 19-36 weeks). Intracardiac potassium chloride injection was used in all the cases. Forty-one (66%) were done prior to24 weeks gestation, 17 (27%) between 24 and 32 weeks gestation and 4 after 32 weeks. The main indication prior to 24 weeks was for chromosomal anomalies whereas between 24and 32 weeks the main indication was for CNS anomalies. All fetocides performed after 32 weeks were for CNS anomalies. Two of these were discordant anomalies in dichorionic twin pregnancies. In both cases the diagnosis was made at 20 weeks but the fetocide was delayed to minimise the risk of iatrogenic prematurity to the healthy twin. Karyotyping was done in 31 cases (51%) and 29 (48%) consented to post-mortems. Conclusion: Identifying major CNS anomalies late in pregnancy presents challenges with regards to the options for management. In cases of discordant anomalies in multiple pregnancies, decisions have to be made to minimise the risk of harm to the normal fetus.OP09.07 TTTS1 protocol: a cluster randomized controlled tr...

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Objectives: Polycystic ovary syndrome (PCOS) is a condition marked by chronic anovulation, hyperandrogenaemia and infertility and affects approximately 5-10% of women of reproductive age. It is kown that relative hyperestrogenism and anovulation are involved in the etiology of benign breast disease, since mammary gland growth is influenced by a critical balance between estrogens and progesteron action. The aim of this study was to evaluate the association between a polycystic ovary syndrome and fibrocystic breast disease. Methods: In this case-control study 93 women aged between 17-36 years, not using oral contraceptives were entered into the sudy. Laboratory, clinical and ultrasound findings were used to diagnose a polycystic ovary syndrome. The study group was consisted of 53 PCOS women and the control group was consisted of 40 women. All patients were performed breast ultrasonography. Fibrocystic breast disease is described as common benign changes involving the tissues of the breast. Results: Mean ages were similar in both groups. Twenty one (39.6%) of 53 women with a PCOS had fibrocystic breast disease. Five (8%) of 40 controls had fibrocystic breast disease. The difference between the groups was statistically significant (P < 0.05). One lipoma, 2 fibroadenoma were determined in a polycystic ovary syndrome group. Controls had one lipoma and 3 fibroadenoma. Conclusions: This study showed a statistically significant association between a polycystic ovary syndrome and fibrocystic breast disease. Women with a polycystic ovary syndrome should be evaluated for fibrocystic breast disease.