OBJECTIVE. The purpose of thisstudywasto determine if tissueharmonicimaging(THI) sonography produced higher quality images than did conventional sonography. SUBJECTS AND METHODS. A prospective studywasperformed on 89 patients tocompare the image quality ofTHI sonography with that of conventional sonography. Each cx amination was performed using THI sonography (transmitted frequency, 2.0 MHz; received frequency, 4.0 MHz) and conventional sonography at 2.5 and 4.0 MHz. The pancreatic area was studied in 60 patients, and other anatomic areas were studied in 68 patients. The images were then graded for penetration, detail, and total image quality. Graders were unaware of the sonographic technique.