A large family with Charcot-Marie-Tooth disease, showing a probable X-linked incomplete dominant inheritance, was studied by linkage analysis. Results, obtained by the use of X chromosome specific DNA probes of known regional location, suggest that the disease locus is linked to the DXYSI locus (i=2.59-at 8=0.00) and to the DXS14 locus and, places the disease locus between the DXYSI locus and the DXS14 locus, near the centromere of the X chromosome. Together with the published data, a distance of 13 cM (i=6.95) was assessed between the disease locus and the DXYSI locus.