Cardiac amyloidosis (CA), a significant condition resulting in infiltrative cardiomyopathy and heart failure with preserved ejection fraction (HFpEF), is caused by extracellular deposition of amyloid fibrils in the heart. Even though this has been known for an extended period, its prevalence in elderly patients with heart failure is increasingly being recognized. Recent advances in diagnosis with non-invasive methods like technetium pyrophosphate-labeled cardiac scintigraphy (i.e., Tc-PYP scan) and treatment options with tafamidis have played a pivotal role in awareness of the burden of this disease. Management of cardiac complications like heart failure, atrial arrhythmias, conduction block, ventricular arrhythmias, coronary artery disease, and aortic stenosis is now more critical than ever. We aim to review and outline the recent advances in diagnoses of CA. We also review management strategies for cardiac complications of CA with a brief summary of disease-modifying therapies.

UNSTRUCTURED From March to June in 2020, most of the world underwent social isolation, mandated quarantine, or lockdown to prevent the excessive spread and eventual casualties from COVID-19. Such isolation meant a dramatic change from routine livelihood. Though the isolation was essential to contain the disease spread, we argue that the drastic change from daily life must have led to several psychological issues. There is a lack of enough evidence and research in the literature about the mental health of the Indian population. This also leads to a lack of awareness of symptoms and presentations of different disorders of mental health in the general public. Therefore, we chose this target population to help us recognize the culture-specific and general effects of lockdown and social isolation on their psyche. The present study has both qualitative and quantitative arms. The qualitative arms of this study aim to analyze the psychosocial and behavioral effects of social isolation and mandated quarantine or lockdown, along with assessing the amount of awareness and knowledge regarding the disease spectrum caused by COVID-19 in the Indian population. The quantitative arm of the study aims to examine the extent of association between psychosocial/behavioral effects and various demographic factors in the said target population, viz. age, sex, etc. The main purpose of the study is to establish the present status of mental health in the general Indian population and the direct effects of social isolation due to the COVID-19 pandemic.

No abstract

No abstract