Signal processing in a multi-variable indirect measurement system and its uncertainties is considered. It was proposed to extend the vector method of estimating uncertainties, given in Supplement 2 to GUM for the use to describe the accuracy of instrumental systems for indirect multivariable measurements. A formula for the covariance matrix of relative uncertainties is also given. As the example, the covariance matrix for indirect measurements of the star form circuit resistances from its terminals was determined and influence of of the measurement channels uncertainties are analyzed.

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