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To show a relationship between degree of carotid arterial stenosis and cerebral blood flow reactivity (RES%) to induced hypercapnia, fluorine-18-fluoromethane and positron emission tomography (PET) was used to study 18 We have studied 18 patients who have strictly unilateral extracranial carotid arterial disease using positron emission tomography (PET), fluoromethane ('8FCH3) and CBF reactivity to induced hypercapnia. In this preliminary study we aimed to non-invasively study the physiological effect of varying degrees of arterial stenosis on the cerebral circulation.

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This study demonstrates that suramin is well tolerated by patients with recurrent high-grade gliomas and may have efficacy in this disease. Its pharmacology seems unaffected by anticonvulsants. As a result of this data, suramin and radiation are now being administered concurrently to patients with newly diagnosed glioblastoma multiforme, with survival as the primary outcome.