To Profa. Dra. Claudia Barros Monteiro Vitorello, for the mentoring, patience and friendship. You are an example of scientist and person for me since that first class when you introduced me the molecular biology. To my mentors at FMC, Vanessa Frare and Eduardo Picelli, for being truly leaders, for the support and encouragement and, mostly important for the commitment with my development. To my boyfriend Wilson, thank you for the partnership and care. To my friends and colleagues of Genomic"s Group, for the friendship. I know I can always count on you. It was always a pleasure the time spent together. To my friends at FMC, Talita Brunhara, Mariana Pistore, Alexsine Vanzela, Dayane Guimarães and Guilherme Salvador for all the friendship and support. I remember each day you were there after 6:00 pm with me.