Objective: To evaluate clinical and histological features of duodenal ulcer in children and adolescents.Methods: Forty-three children with duodenal ulcer were prospectively and consecutively evaluated in a 6 year period (7.2 patients per year). Evaluation included clinical questionnaire focused on dyspeptic symptoms, physical examination, and digestive endoscopy with gastric biopsies for histological examination and Helicobacter pylori detection.Results: Diagnostic age ranged from 4 years and 8 months to 17 years and 4 months (mean age: 12 years and 4 months). Abdominal pain was the main symptom (39/43, 90.7%), which was epigastric in 31/39, periumbilical in 7/39, and nocturnal in 27/39. Other symptoms were loss of appetite (32/43, 74 ResumoObjetivo: Avaliar as características clínicas e histológicas de crianças e adolescentes com úlcera duodenal.Métodos: Foram avaliadas prospectiva e consecutivamente 43 pacientes com úlcera duodenal ao longo de 6 anos (7,2 pacientes por ano). A avaliação consistiu de questionário clínico de sintomas dispép-ticos, exame físico e endoscopia digestiva com biópsias gástricas para exame histológico e detecção do Helicobacter pylori.Resultados: A idade no diagnóstico variou de 4 anos e 8 meses a 17 anos e 4 meses (mediana = 12 anos e 4 meses ARTIGO ORIGINALGastrite crônica associada à infecção por Helicobacter pylori está presente na grande maioria das crianças com úlcera duodenal primária, havendo consenso para o tratamento de erradicação da bactéria, pela diminuição acentuada do índice de recidivas ulcerosas 1 . A colonização da mucosa gástrica por H. pylori, bacilo gram-negativo, microaerofílico, espiralado, atualmente ocorre em uma minoria das crianças de países desenvolvidos, ao contrário das crianças de países em desenvolvimento, sendo a prevalên-cia até 10 anos de idade de 5-10% e até 80%, respectivamente 2 . Os principais fatores de risco para contrair a infecção são: viver em país em desenvolvimento e ser criança com pais infectados e de baixo poder aquisitivo 3 . A maioria dos pacientes é assintomática, estimando-se que cerca de 15% evoluem para úlcera péptica e 1% para câncer gástrico 4 . Após a instalação da gastrite, a bactéria geralmente persiste por toda a vida, sendo rara a erradicação espontânea. Não há conclusão definitiva a respeito da influência dos fatores de virulência da bactéria, assim como da resposta do hospedeiro ou das condições ambientais que poderiam interferir no curso evolutivo desta afecção.
Objective: To evaluate clinical and histological features of duodenal ulcer in children and adolescents.Methods: Forty-three children with duodenal ulcer were prospectively and consecutively evaluated in a 6 year period (7.2 patients per year). Evaluation included clinical questionnaire focused on dyspeptic symptoms, physical examination, and digestive endoscopy with gastric biopsies for histological examination and Helicobacter pylori detection.Results: Diagnostic age ranged from 4 years and 8 months to 17 years and 4 months (mean age: 12 years and 4 months). Abdominal pain was the main symptom (39/43, 90.7%), which was epigastric in 31/39, periumbilical in 7/39, and nocturnal in 27/39. Other symptoms were loss of appetite (32/ 8%).Helicobacter pylori infection was detected in 41/43 (95.3%). All infected patients presented acute chronic gastritis in antrum, with lymphomononuclear infiltrate predominance in 92% of them. Eradication of the bacterium occurred in 68.3%. Ulcer healing occurred in all eradicated patients and in 89% of non-eradicated patients.Conclusion: Duodenal ulcer was associated with chronic gastritis due to Helicobacter pylori in the majority of patients. Many complications occurred, especially upper digestive bleeding.
Duodenal ulcer was associated with chronic gastritis due to Helicobacter pylori in the majority of patients. Many complications occurred, especially upper digestive bleeding.
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