We report a case of diffuse melanosis secondary to metastatic malignant melanoma in a Nelore bull. Clinical signs included isolation from the herd, epistaxis, hyperthermia, pale ocular membranes, mucoid diarrhea and dark urine. Despite anti-inflammatory and antibiotic therapy, the bull died 45 days after the onset of the clinical signs. The most striking lesion was diffuse black discoloration to the visceral organs including liver, spleen, lungs, lymph nodes, and kidneys; all these affect organs were moderately enlarged”. The urine was black. Histologically, 50-80% of the parenchyma of the liver, spleen and lymph nodes was obliterated by aggregates of melanin-loaded neoplastic melanocytes. Those neoplastic cells also occurred within capillaries of the liver, spleen, lymph nodes, urinary bladder, lungs and kidneys. Immunohistochemistry of neoplastic melanocytes was positive for Melan A and PNL2 markers. Abundant brown to black pigment was found in melanophages in the lungs, confirmed by IBA1 immunohistochemistry.

Brucellosis is one of the most important and widespread bacterial zoonotic diseases worldwide, and it is transmitted to humans from various sources, including direct contact with infected animals and the ingestion of contaminated products, including unpasteurized milk. There are only a few epidemiological studies on said disease in humans in Western Santa Catarina, a region instantiated by agriculture. Thus, the objective of this study was to characterize the epidemiological aspects of human brucellosis reported in Western Santa Catarina from 2013 to 2018. The data were provided by the Epidemiological Surveillance Board (Diretoria de Vigilancia Epidemiologica). The frequency of the disease in humans and the epidemiological profile of confirmed human cases were evaluated. Cases that were screened positive and those that were confirmed and submitted to the therapeutic protocol were analyzed. During the study period, 3,671 people were tested, of which 12.34% were screened positive (453/ 3,671) and 3.40% were confirmed (125/3,671). The year with the highest number of people testing positive was 2015 (123 cases), and 2018 was the year with the highest number of confirmed cases (39 cases). Confirmed cases predominated in males (48.8%), self-declared white (22.4%), aged 20-59 years old (60%), with incomplete primary education (22.4%), of rural origin (59.2%), with occupational contact with cattle (64.8%), engaged in professions directly linked to agricultural and livestock activities (55.5%), and who reported consumption of unpasteurized dairy products (59.2%). No seasonal variation was observed in case numbers. The results demonstrated that brucellosis is an endemic disease in Western Santa Catarina.

Os osteossarcomas extra esqueléticos são neoplasmas raros, responsáveis por cerca de 2% dos casos de osteossarcoma em cães. Devido à escassez de relatos desta neoplasma, o presente trabalho tem como objetivo descrever um caso raro de osteossarcoma em tiroide em uma cadela atendida na Superintendência Unidade Hospitalar Veterinária Universitária (SUHVU) da UFFS. Animal apresentava aumento de volume em região cervical ventral de consistência firme, com aproximadamente 7,3 centímetros de comprimento por 5,0 centímetros de largura, compatível com topografia da glândula tiroide direita. O animal foi submetido a nodulectomia, e o material encaminhado para avaliação histopatológica e imuno-histoquímica. Entretanto, após retorno da anestesia e liberação do paciente para cuidados domésticos, cerca de duas horas depois o paciente foi a óbito e, posteriormente, submetido à necropsia. Na necropsia os pulmões apresentavam nódulos multifocais de 3 a 5 milímetros de diâmetro, de consistência firme e superfície irregular que não foram possíveis de visualização no exame radiográfico. A avaliação histológica revelou tratar-se de osteossarcoma osteoblástico produtivo em tireóideo e a avaliação das formações nodulares do pulmão revelou ser metástase do mesmo. Na imuno-histoquímica da tireoide, foi possível observar marcação positiva de TTF-1 em glândulas remanescentes, confirmando a localização tireoidiana do tumor. A expectativa de vida dos animais acometidos pelo neoplasma em questão é de dias a meses, no presente caso além do animal apresentar o osteossarcoma em tiroide que é considerado bastante agressivo e com prognóstico ruim, acredita-se que as hemorragias encontradas durante o exame necroscópico contribuíram para a ocorrência do óbito do animal.