Postoperative concurrent administration of high-dose cisplatin with radiotherapy is more efficacious than radiotherapy alone in patients with locally advanced head and neck cancer and does not cause an undue number of late complications.

Subject to the usual caveats of retrospective subgroup analysis, our data suggest that in locally advanced head and neck cancer, microscopically involved resection margins and extracapsular spread of tumor from neck nodes are the most significant prognostic factors for poor outcome. The addition of concomitant cisplatin to postoperative radiotherapy improves outcome in patients with one or both of these risk factors who are medically fit to receive chemotherapy.

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Improved survival in patients with locally advanced prostate cancer treated radiotherapy and goserelin Bolla, M.; González González, D.; Warde, P.; Dubois, J.B.; Mirimanoff, R-O.; Storme, G.; Bernier, J.; Kuten, A.; Sternberg, C.; Gil, T.; Collette, L.; Pierart, M.