No abstract

The flexibility of DNA is of central importance in biology, medicine, materials science, and mechanical engineering. In this study, we report an unprecedented electrochemical approach for investigating the flexibility of a short (typically 20-base), surface end-tethered single-stranded synthetic DNA oligonucleotide and of its postformed DNA duplex, taking as an example the homopolymer (dT)20 sequence in the regime of very high ionic strength ( approximately 1 M).

The electrochemical oxidation of dihydronicotinamide adenine dinucleotide (NADH) was studied in buffered aqueous media (pH 7.0) by single and multiple sweep voltammetry and pulse (normal, differential, and derivative) techniques at rotating disk electrodes, and by single sweep voltammetry at stationary disk electrodes; two different kinds of glassy carbon and one type of pyrolytic graphite were used to prepare the electrodes. The