Serotonin syndrome is caused by excessive activation of serotonin receptors in the central nervous system. 1) This may occur when an overdose of a drug that increases serotonin levels is utilized or when two serotonergic drugs are used concurrently. 2) Serotonergic drugs include monoamine oxidase inhibitors (MAOIs), selective serotonin receptor inhibitors, serotonin-norepinephrine reuptake inhibitors, tricyclic anti-depressants, antipsychotics, opiate analgesics, etc. 1,[3][4][5][6][7][8][9][10][11][12][13] The symptoms of serotonin syndrome vary in severity. Mild cases may only experience tachycardia without fever and in some occasions autonomic findings such as diaphoresis, shivering, or mydriasis can be recognized on physical examination. 2) Severe cases can be life-threatening, with high blood pressure and tachycardia, sustained clonus, muscle hypertonicity, and a