TNF-• induces some proinflammatory cytokines including IL-1ß, IL-6, IL-8, and itself by activation of NF-κB or MAPKs (p38, JNK, ERK). These cytokines play important roles in various inflammatory skin diseases, such as psoriasis. Recently it was also reported that expression of cyclin E is upregulated by ERK pathway after TNF-• treatment. However, it was unknown whether curcumin, showing inhibitory effects on NF-κB and MAPKs, attenuates the expression of TNF-•induced IL-1ß, IL-6, IL-8, and TNF-• as well as cyclin E expression in HaCaT cells. In this study, we investigated the inhibitory effect of curcumin on expression of proinflammatory cytokines and cyclin E in TNF-•-treated HaCaT cells. We found that curcumin inhibited the expression of TNF-•-induced IL-1ß, IL-6, and TNF-•, but not IL-8, in TNF-•-treated HaCaT cells as well as the TNF-•-induced cyclin E expression. In addition, curcumin inhibited the activation of MAPKs (JNK, p38 MAPK, and ERK) and NF-κB in TNF-•-treated HaCaT cells. Taken together, curcumin exerts anti-inflammatory and growth inhibitory effects in TNF-•-treated HaCaT cells through inhibition of NF-κB and MAPK pathways.

No abstract

No abstract

Combination therapy of fractionated microneedle RF and fractional CO2 laser is a safe treatment protocol with a positive therapeutic effect on striae distensae.

No abstract