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Chair and Clinic Of Endocrinology UJCM A case of thyroid cancer followed by metachronous cancers and a pituitary tumour Based on cancer registries, the risk of second primary malignancies in patients with DTC increases by 30%. In our case report we aimed at understanding the patomechanism of metachronous primary tumours in patients with thyroid cancer. In a 71-year old female surgery of nodular goitre (1988), followed by papillary thyroid cancer (pT3NxMx) surgery (2008) and complementary 131-I treatment (2009), were performed. In diagnostic WBS (May 2010) no pathologic 131-I uptake, 0,3 ml thyroid volume (USG), and no enlargement of lymph nodes were stated. Tg concentration after rhTSH stimulation was 10,7 ng/ml. Consecutive 131-I therapy followed (August 2010). Due to increase in thyroglobulin concentration, WBS was performed (2014), with no pathologic 131-I uptake rhTSH-stimulated TSH (351,9 uU/ml) and Tg (13,8 ng/ml).

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