BackgroundPatients presenting with a mass require tissue biopsy for histological diagnosis and treatment. Fine needle aspiration (FNA) is offered as an atraumatic, well tolerated, and inexpensive method for obtaining a biopsy from these lesions.ObjectivesIn this study we evaluated the accuracy of FNA as an atraumatic method among patients with nonthyroidal masses for diagnosis of neoplastic masses compared to open surgery.Patients and MethodsIn a cross-sectional study, 65 patients with a head and neck masses (nonthyroidal) referred to us from 2004 to 2009. Those who had both FNA and open biopsy (the gold standard) were assessed for specificity, sensitivity, positive and negative predictive values of FNA in diagnoses.ResultsSixty-five cases with both definite diagnoses of open biopsy and FNA were assessed. The mean (± standard deviation) age of patients was 39.96 ± 19.69 years (range 10 to 82 years). Twenty-five (40.8%) subjects were categorized as malignant neoplasms, 16 (19.4%) as benign neoplasms, and 24 (39.8%) as non-neoplastic lesions. The sensitivity, specificity, positive and also negative predictive values of FNA in the diagnosis of neoplastic masses were 95%, 85%, 92.68%, and 91.66% respectively, and the diagnostic accuracy was 92.3%.ConclusionsIt seems that FNA is a useful atraumatic diagnostic technique with a high diagnostic accuracy which can provide a highly sensitive diagnosis with low false positive diagnoses in patients with nonthyroidal masses.

Gastric cancer (GC) is the most frequent leading cause of cancer-associated mortality worldwide that is linked to poor prognosis due to the lack of appropriate biomarkers. Our aim was to evaluate the MUC5AC and Oct-4 expression levels in GC and to assess their association with clinical factors. Immunohistochemical analysis (IHC) and qRT-PCR were performed in GC patients to examine the MUC5AC and Oct-4 expression levels. The mRNA level of MUC5AC was significantly decreased in tumour tissues compared with non-cancerous tissues (1.11 ± 0.69 vs 3.7 ± 0.71; P = .024). On the other hand, Oct-4 mRNA level was upregulated in tumour tissues as compared to normal tissues (2. 86 ± 0.78 vs 0.87 ± 0.54; P = .0015). Decreased expression of MUC5AC was detected in 27 patients (67.5%), while high to moderate expression levels were observed in 13 cases (32.5%), but in normal tissues the expression levels of MUC5AC were increased (P = .001). The decreased expression of MUC5AC was associated with aggressive tumour characteristics, such as TNM stage (P = .023), histologic type (P = .012) and lymph node metastasis (P = .001). High expression of Oct-4 was detected in 24 tumour tissues (60%), while 16 cases (40%) showed low expression level. Increased Oct-4 expression was correlated with clinicopathological characteristics such TNM stage (P = .002), histologic type (P = .008) and lymph node metastasis (P = .001). Our results showed that high Oct-4 expression and the reduction of MUC5AC expression may be involved in the progression and an unfavorable prognosis of GC.

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Introduction: Complication after inguinal hernia repair is one of the challenging problems after inguinal hernia repair. This study aimed to compare the complications of three common surgical methods in inguinal hernia repair, Bassini, Lichtenstein, and Preperitoneal methods (with anterior approach). Methods: In this prospective study, patients who underwent inguinal hernia repair surgery in Baqiyatallah Hospital from June 2019 to May 2020 were included. Patients were allocated in three groups: Bassini, Lichtenstein, and Preperitoneal (with anterior approach), based on surgeons' opinions. Postoperative pain, hematoma and seroma, wound infection, recurrence, and also we assed postoperative satisfaction after surgery. Results: The mean age of patients was 49.90 ± 16.44 years, and 92.5% of patients were male. Of the total patients, 6.8% had an infection and there was no significant difference in the distribution of infection in the groups (P=0.230). The mean of pain in all patients was 2.37 ± 1.10. There was no significant difference between the three groups in the mean of pain (P = 0.253). There was no significant difference in the distribution of recurrence in the groups (P=0.356). There was no significant difference in the distribution of testicular swelling in the groups (P=0.421). No postoperative hematoma and seroma were reported in the groups. The mean of satisfaction in all patients was 93.61±19.63. There was no significant difference between the three groups in the mean of satisfaction (P = 0.156). Conclusion: The results showed that infection, pain, and recurrence rate in the Preperitoneal group were lower than the other groups, although this difference was not significant. Also, testicular swelling, hematoma, and seroma as well as patients’ satisfaction were similar between groups.

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