200 ml. of methanol was reduced in a low pressure hydrogenator over 24 hr. The insoluble solid and catalyst were filtered and recrystallized from 550 ml. of nitromethane to give 13.4 g. (63.5%). An analytical sample decomposed at 224-225°, Xmax. 5% EtOH 348 µ (< 20,750). The infrared spectrum (mull) had bands at 3.0, 3.05, 5.8 and 6.3 µ.

F A method for the determination of furazolidone and nitrofurazone in chicken tissues is based on the formation and colorimetric estimation of 5nitro-2-furaldehyde phenylhydrazone. A chromatographic separation of the phenylhydrazone from nonspecific liver chromogens permits visual demonstration of the nitrofuran in concentrations as low as 0.5 p.p.m. and permits quantitative determination of these nitrofurans in chicken liver at 1 to 5 p.p.m. with an accuracy of 92 to 104%. A nonchromatographic method is used for fat and muscle residue analysis. The recoveries for these tissues ranged from 97 to 1 0 8~o at 1 and 5 p.p.m. HE INCREASING use of furazolidone, T 3 -(5nitrofurfurylideneamino) -2oxazolidinone (Furoxone), and nitrofurazone, 5-nitro-Zfuraldehyde semicarbazone (Furacin), (Structures 1 and 2) in the treatment and control of various poultry diseases (5, 7) has em-Structure 1. Nitrofurazone, 5-nitro-2-furaldehyde semicarbazone

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Tubular secretion of nitrofurantoin has been demonstrated in the dog and the chicken. This secretion has been localized in the proximal tubule and has been shown to be due to the action of the weak acid transport system. Reabsorption of nitrofurantoin by passive, nonionic diffusion has also been illustrated.