Enantioselective total syntheses of the antitumor alkaloids, (+)-narciclasine and (+)-pancratistatin, are reported. These syntheses feature a stereo-and regiocontrolled aryl enamide photocyclization to construct a common, advanced intermediate possessing a trans-fused BC substructure. Differential functional group interchange in the C-ring of this phenanthridone core structure allows for the production of the two target natural products in enantiomerically pure form.

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