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first is that exophthalmos in experimental animals is not produced by thyroid extract, but by pituitary extract, and more easily when the animals are thyroidectomized. In the series of cames that we have seen at our hospital, exophthalmos does not decrease after thyroidectomy, although we know definitely that it may happen later on, but in the early stage it does not decrease, and actually increases in 50 per cent of the cases following thyroidectomy. In ophthalmopathy in man and animal alike there is edema and cellular infiltrhtion, and in the later stages, fibrosis, and the other late manifestations following a radiation lesion.Goiterogenic drugs, such as thiouracil and thiourea, interfere with the formation of the thyroid hormone.