Canine distemper virus has been isolated in dog lymphocyte cultures from the brains of three javelinas that became moribund with signs of encephalitis. Canine distemper viral antigen was demonstrated predominantly in neurons and morbillivirus-like structures were seen by electron microscopy in brains of diseased animals. Serological studies suggest that CDV infection may be common in javelinas.

Infectious fibromas developed in eight domestic rabbits that were all kept in outside cages. Each rabbit had a single cutaneous tumor. Six of these tumors, which were studied by light microscopy, consisted of tumor cells resembling fibroblasts and large areas of inflammation. The overlying epidermis was hyperplastic and contained easily recognizable intracytoplasmic inclusion bodies. Inclusion bodies were also in subepithelial fibroma cells. Electron microscopy of three of these tumors revealed typical pox-virus inclusions, sites of viral replication, maturation, and mature particles in epithelial cells of the epidermis and in subepithelial tumor cells. Virus was not seen in inflammatory cells or leukocytes within vascular channels.

Abstract. Visceral leishmaniasis was diagnosed in a 2-year-old male Great Dane imported from Greece. The clinical signs included anemia, diarrhea, weight loss, proteinuria, and hyperglobulinemia with increases in a*-and y-regions. At necropsy there was plasmalymphocytic and macrophage infiltration of spleen, macrophage infiltration of bone marrow, intracellular organisms of macrophages having the ultrastructural characteristics of Leishmania species, and severe amyloidosis of the spleen, liver, and kidney.