HighlightsSNP rs1143684 results in either a Phe or Leu at position 47 in human NQO2.NQO2-L47 has a slightly lower kcat/Km; it also has a lower Ki,app with resveratrol.NQO2-L47 is more unstable to proteolysis and thermal denaturation.NQO2-F47 (but not NQO2-L47) shows negative cooperativity towards resveratrol.NQO2-L47 exists as multiple conformers in solution.
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