There appear to be 2 distinct mechanisms for linezolid-induced cytopenias. While anemia is reversible and manageable with transfusions, thrombocytopenia can be a treatment-limiting toxicity. The ability to treat through an immune-mediated cytopenia with IVIG may be beneficial for critically ill patients with few therapeutic options.

A b s t r a c t We evaluated 48 archival cases of acute erythroleukemia and divided them into 3 groups: M6a

Monoclonal antibodies specific for the five major glycoproteins of herpes simplex virus type 1 (HSV-1) were tested for their capacity to mediate immunity to ocular HSV-1 infection. The specificity of the immunoglobulin made by each monoclone was determined by immunoprecipitation of [14C]glucosamine-labeled polypeptides from detergent-solubilized HSV-1-infected cells. Of the five monoclonal antibodies studied, two immunoprecipitated glycoproteins gA/B, one immunoprecipitated glycoprotein gC, one immunoprecipitated glycoprotein gD, and one immunoprecipitated glycoprotein gE. All five were effective in passively MATERIALS AND METHODS Cells and media. Vero cells were grown in minimal essential medium (MEM) supplemented with 5% newborn calf serum (NBCS), sodium bicarbonate, and antibiotics. The P3X63Ag8.653 cell line (obtained from John Kearney, Birmingham, Ala.