A patient who erroneously took oral methotrexate daily rather than thrice weekly for psoriasis developed multiple manifestations of methotrexate toxicity.

Nineteen derivatives of (1 R)-(+)camphor with deutero, fluoro, bromo, iodo, keto, and hydroxyl functionalities at carbons 3, 5, 8, or 9 have been examined using 13C NMR. The chemical shifts for each carbon of these substituted camphor derivatives have been assigned using broad band decoupling and the refocused INEPT pulse sequence. INTRODUCTIONThe importance of norborneol derivatives to the understanding of the 13C NMR of other bicyclic systems has been well established.'In the course of our recent studies of the metabolism of camphor by the cytochrome P-450-CAM273, nineteen derivatives of (1R)

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