Background/Aims: The aim of this study was to perform a psychometric validation of the Czech version of the Quality of Life – Alzheimer’s Disease scale (QoL-AD) for patients with early-stage dementia. Methods: The sample included 212 patient-proxy pairs. For convergent validity, the Czech version of the Bristol Activities of Daily Living Scale (BADLS-CZ), the Short Physical Performance Battery (SPPB), and the Geriatric Depression Scale (GDS) were used. Results: The reliability of the QoL-AD for patients and caregivers was good (Cronbach’s α = 0.85, ICC = 0.25–0.54). A positive correlation existed between the QoL-AD and the SPPB, and negative correlations existed between the QoL-AD and the BADLS-CZ as well as between the QoL-AD and the GDS. Factor analysis resulted in a three-factor solution (physical and mental health, family life, and social security). Conclusion: The Czech version of the QoL-AD has good psychometric properties in compliance with international recommendations.

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