Writing Committee for the REMAP-CAP Investigators IMPORTANCE The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.OBJECTIVE To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19. DESIGN, SETTING, AND PARTICIPANTSThe ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or confirmed COVID-19 between March 9, 2020, and January 18, 2021, within at least 1 domain; 2011 critically ill adults were randomized to open-label interventions in the immunoglobulin domain at 129 sites in 4 countries. Follow-up ended on April 19, 2021. INTERVENTIONSThe immunoglobulin domain randomized participants to receive 2 units of high-titer, ABO-compatible convalescent plasma (total volume of 550 mL ± 150 mL) within 48 hours of randomization (n = 1084) or no convalescent plasma (n = 916). MAIN OUTCOMES AND MEASURESThe primary ordinal end point was organ support-free days (days alive and free of intensive care unit-based organ support) up to day 21 (range, −1 to 21 days; patients who died were assigned -1 day). The primary analysis was an adjusted bayesian cumulative logistic model. Superiority was defined as the posterior probability of an odds ratio (OR) greater than 1 (threshold for trial conclusion of superiority >99%). Futility was defined as the posterior probability of an OR less than 1.2 (threshold for trial conclusion of futility >95%). An OR greater than 1 represented improved survival, more organ support-free days, or both. The prespecified secondary outcomes included in-hospital survival; 28-day survival; 90-day survival; respiratory support-free days; cardiovascular support-free days; progression to invasive mechanical ventilation, extracorporeal mechanical oxygenation, or death; intensive care unit length of stay; hospital length of stay; World Health Organization ordinal scale score at day 14; venous thromboembolic events at 90 days; and serious adverse events. RESULTS Among the 2011 participants who were randomized (median age, 61 [IQR, 52 to 70] years and 645/1998 [32.3%] women), 1990 (99%) completed the trial. The convalescent plasma intervention was stopped after the prespecified criterion for futility was met. The median number of organ support-free days was 0 (IQR, -1 to 16) in the convalescent plasma group and 3 (IQR, -1 to 16) in the no convalescent plasma group. The in-hospital mortality rate was 37.3% (401/1075) for the convalescent plasma group and 38.4% (347/904) for the no convalescent plasma group and the median number of days alive and free of organ support was 14 (IQR, 3 to 18) and 14 (IQR, 7 to 18), respectively. The median-adjusted OR was 0.97 (95% credible interval, 0.83 to 1.15) and the posterior probability of futility (OR <1.2) was 99.4% for the convalescent plasma group compared with the no convalescent plasma group. The treatment effects were consistent across the primary outcome and the 11...

The spiders (Araneae) of pure pine and birch stands on restored open dump sites in Saxony and Brandenburg (Germany). The spider communities of four restored, afforested pure stands of first generation pine, birch and birch-robinia in the postmining landscape and one natural pine forest of the Lower Lusatia (Germany: Saxony and Brandenburg) were investigated. From 1997-98 a total of 6368 spiders were caught using stemeclectors and pitfall traps. More than 50% of the specimens collected were juveniles. The remaining individuals were identified and represent 1 23 species from 23 families. Among them several taxa are listed in the Red Data Lists of Germany (n = 1 6), Brandenburg (n = 1 3) and Saxony (n = 1 4). One species, Clubiono leucaspis is rare in Germany and new to Saxony.When comparing afforested stands of pine on postmining areas with natural ones the species Coelotes terrestris (Amaurobiidae) was observed exclusively in the latter. The absence of this species on restored sites seems to indicate a disturbance of the soil up to almost 60 years after the end of restoration. According to pitfall trapping in three pine forests the increasing biomass of spiders indicates a high predation rate at the oldest site, whereas the highest species diversity was found on younger, rehabilitated sites.

Dieser Text prüft, inwiefern Expertinnen und Experten, die sich beruflich mit dem Themenbereich Radikalisierung beschäftigen, für den Radikalisierungsverlauf die gleichen Aspekte auf der Mikro-, Meso- und Makroebene als zentral erachten, wie theoretische Modelle dies tun. Grundlage dafür ist das Modell, das im früher in der NK erschienenen Text „Modelle von Radikalisierungsverläufen - Einflussfaktoren auf Mikro-, Meso und Makroebene“ (Bögelein/Meier/Neubacher, 2017) herausgearbeitet wurde. Es zeigt sich, dass die Expertinnen und Experten die gleichen Themen als relevant empfinden.

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