A modular and scalable strategy, which converts 3-methylglutaric anhydride to 2-oxopiperidines bearing at least three contiguous stereocenters is described.
A flexible approach to sp3-rich N-heterocyclic sulfones, which hinges on the efficient annulation of an easy-to-prepare sulfone-embedded anhydride with 1,3-azadienes and aryl aldimines, is described.
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