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Primary malignant melanomas of the central nervous system (CNS) are rarely seen entities in the clinical routine. Primary amelanotic melanomas are even rarer. In our literature review, we found only six case reports of primary amelanotic CNS melanomas. Our case report describes the course of a 71-year-old man with a primary amelanotic CNS melanoma with secondary spread to the spine.

Both varicosis and postthrombotic syndrome are manifestations of chronic venous disease - a widespread disease. Even at an early stage there are visible vascular symptoms, feeling of heaviness and tendency to swelling. In advanced stages, skin alterations and chronic wounds follow. Chronic venous insufficiency as a progressive disease can lead to significant limitations in the quality of life. Adequate diagnosis and therapy is therefore essential. A causal therapy that removes varices or occluding processes should be targeted whenever possible. Accompanying or if a causal therapy is not desired or possible, a symptom-oriented treatment can be considered. The therapy regimen should be individually tailored depending on the leading clinical symptoms, the comorbidities and the patient's wishes. Conservative therapy is the basic measure and should be known to every practitioner.

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