It has Iiwn known for sotnc* tinir that many continuous rhemiriil rrac-tors givr thc. grrutrst ronvrrsion when axial dispersion i* niininiizrd, i.r., whrn plny flow o w n r s . This paprr ronsidrrs the problrni of attaining phig flow in runtinntins flow syktrnik. Thc grunic~triral runfiguration of a tubr wound into 11 helix is wuggrstrd 11s a convrnirnt and rflicirnt tiwans of producing acrondery rurrrnts whirh promotr ~) l i t g flow. On t h r Iisris o f trirrc-r distribution tcsts and prcssnrv drop data it is ronrlusivrly shown that hrliral roils a r r fiir snprrior to straight tuhrs o r packed beds in minimizing iixitil diwpwsion iincl approaching plug flow. t has been known for SOIIIC tinic that many continuous flow

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Location processes are constitutive for the formation of economic landscape. Largest enterprises represent one of the most important units of territorial economies. Their role is palpable mainly in the sphere of employment, technological level, value chains, competition as well as overall economic power. It is far from surprising that the weight of enterprise headquarters is higher than that of their affiliates. Therefore, the main objective of our article is to analyze and assess the development of spatial organization of one hundred largest enterprise head offices in the Czech Republic from both quantitative and qualitative perspectives. Due to data limitations, size of the enterprise is measured by its turnover. Spatial distribution of one hundred largest Czech enterprises and its development over time represent the focal point of our evaluation from quantitative point of view. The analysis was based upon annually published top 100 databases. Qualitative assessment is underpinned by the results of the questionnaire, which was focused on particular location factors accentuated by largest enterprises. Consistency analysis and exploratory factor analysis provide us with useful instrument for the evaluation of qualitative dimension of the issue and help us to conceptualize location preferences of largest enterprises in the country.

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