A new series of non peptide angiotensin(A-II) receptor antagonist has been prepared. ThisN-(biphenyl methyl) imidazolese.g. 5-substituted (amino) -2- phenyl-1-(2ʼcarboxy biphenyl-4-yl) benzimidazoles differ from the previously reported and related compounds in that they produce a potent hypertensive effect upon oral administration. The earlier series were generally active only when administered intravenously. It has been found that 2’-position of biphenyl is essential. Only ortho substituted acid possess both high affinity for the AII receptor and oral anti-hypertensive potency.

Aim of present research work was formulation and development of bilayer tablets of Ketoprofen to reduce the side effects of Ketoprofen and to improve the therapeutic benefits and patients' compliance to treatment. Bi-layer tablets of Ketoprofen were prepared by direct compression technique using excipients like MCC, superdisintegrant, aspartame, colour agent were mixed properly shifted from sieve no 40. Before compression; add talc magnesium stearate mixed it well. Formulations with optimal properties have been selected to obtain bi-layer tablets of adequate quality. The in vitro dissolution study of the prepared bilayer tablets showed a controlled release of active drugs over a period of 24 hours.