BACKGROUNDThe primary role of the renal biopsy is to provide a diagnosis that allows the clinician to make an informed prognosis and assign lesion-specific therapy. Renal biopsy has become an indispensable tool in the investigation of medical diseases of the kidney because early diagnosis and treatment can prevent longterm complications. The use of Light microscopy and Immunofluorescence alone may be sufficient to diagnose common glomerular diseases encountered in clinical practice. Hence, the present study was conducted to study and evaluate the glomerular pathology on the basis of light microscopic and immunofluorescence findings in renal biopsies of patients presenting with features of nephritic syndrome and establish a diagnosis. MATERIALS AND METHODSA descriptive study was done to analyse the histopathology and immunofluorescence pattern of renal biopsies of patients presenting with features of Acute Glomerulonephritis. For this all renal biopsies received in the Department of Pathology from April 2015 to April 2016 which met the defined criteria were analysed. RESULTSAmong the 31 cases studied, 9 (29%) cases of Glomerulonephritis were Non-IgA mesangioproliferative Glomerulonephritis, 6 (20%) cases were IgA Nephropathy, 9 (29%) cases were Diffuse Endocapillary Proliferative Glomerulonephritis (DEPGN), 1 (3%) case was Membranoproliferative Glomerulonephritis (MPGN), 2 (6%) cases were of Lupus Nephritis and 4 (13%) cases were Tubulointerstitial Nephritis (TIN). 25 (80%) cases showed immunoglobulin deposits on immunofluorescence study. Of these, 10 (40%) cases showed mesangial immunoglobulin deposits, 12 (48%) cases showed granular immunoglobulin deposits along the capillary wall and 3 (12%) cases showed linear immunoglobulin deposits along the capillary wall. CONCLUSIONImmunofluorescence plays a vital role in elucidating the presumed pathogenesis in glomerular lesions and helps to arrive at a final diagnosis when combined with light microscopic findings.