New medication combinations are introduced every day. As a result, various diseases and disorders are treated using a combination of several therapeutic medicines that each have a somewhat distinct mechanism of action. Therefore, it is crucial to develop methods of analyzing medicines employing a range of methods that may be utilized. A UV 730d (dad) absorbance detector, a 20 L injection loop, a sp 930d pump, a 4.6 by 100 mL C18 column (Agilent), and Chemstation software are all included in the setup: approximately 60 water and 40% methanol (pH 3.0 adjust with OPA). Maximum effi ciency was achieved when the system was operated at a wavelength of 233 nm. The procedure’s effi cacy was confi rmed by testing it against ICH guidelines. These techniques were found to be linear, precise, broad, and stable. The procedure was found to be easy, accurate, exact, aff ordable, and easy to use again and again. This means that olmesartan and hydrochlorothiazide, in both bulk form and fi nished products, can be tested for quality using the proposed methodologies.