A mild, greener approach toward thioamide synthesis has been developed. Its unique features include water-mediated reaction with no input energy, additives, or catalysts as well. The presented protocol is attractive with readily available starting materials and the use of different array amines, along with a scaled-up method. Biologically active molecules such as thionicotinamide and thioisonicotinamide can be synthesized from this procedure.

Direct installation of amine and sulphur with 1, 1-dibromoalkenes for thioamide synthesis has been achieved in a water medium. Presented green protocol bears more selectivity for thioamide with synthetic utility....