Abstract:2-alkyl-6-bromo-3,1-benzoxazine-4-one (2) is synthesized by treating p-Bromoanthranilic acid and Acetylechoride or Benzoylchloride. Reaction of 2-alkyl-6-bromo-3,1-benzoxazine-4-one (2). with hydrazinehydrate furnish the corresponding 3-Amino-2-methyl-6-bromoquinazoline-4(3H)-one (3) which on reaction with benzaldehyde afford N,N -arylidene derivative (4). Reaction of 4 with various diazonium salts yields 6-bromo-2-alkyl/aryl-3{[phenyl(phenyldiazenyl)methylene]amino}quinazolin-4(3H)-one .

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Conventional and Microwave-Assisted Synthesis of Pyrazole Derivatives andScreening of Their Antibacterial and Antifungal Activities. -Three series of novel quinolylpyrazole derivatives (IV), (VI) and (VIII) are synthesized by condensation reactions of propenone derivatives (III) with hydrazine or semicarbazide derivatives under conventional heating or microwave irradiation conditions. In the conventional method, the yield is lower as compared to the microwave irradiation method demonstrating that the effect of microwaves is not purely thermal. Some of the synthesized pyrazole derivatives show good antibacterial activities. Moreover, all the compounds exhibit mild to moderate activity against Candida albicans.

. -The antimicrobial screening of all synthesized compounds shows moderate to good activity against different microorganisms. Compared to conventional thermal heating (6 h) the microwave-assisted chemical syntheses give higher yields at shorter reaction times.-(RANA, P. B.; PATEL, J. A.; MISTRY*, B. D.; DESAI, K. R.; Indian J.

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