A convenient synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidine was carried out by the reaction of various ketene dithioacetals with 5-amino 1,2,4-triazole in methanol in presence of sodium methoxide. The newly synthesized compound were characterized by 1H NMR, 13 C NMR, IR, MS, elemental analysis and screened for their antimicrobial activity against various strains of bacteria and fungi.

A library of functionalised 1,2,3-triazolo[1,5-a]pryrimidine derivatives has been synthesized by one pot multicomponenet reaction. All synthesized novel compounds were characterised by 1 H NMR, IR, mass and elemental analysis. Compounds were also screened against bacterial and fungle strain.

A library of functionalised 1,2,3-triazolo[1,5-a]pryrimidine derivatives has been synthesized by one pot multicomponenet reaction. All synthesized novel compounds were characterised by 1H NMR, IR, mass and elemental analysis. Compounds were also screened against bacterial and fungle strain.

Various ketene dithioacetals of acetoacetanilides were reacted with guanidine nitrate in the presence of base to produce the 2-amino-4-isopropyl-6-alkoxy-N-arylpyrimidine-5-carboxamide derivatives with good yields. All the synthesized compounds were characterized by mass, NMR and IR and also evaluated for antimicrobial activity against five different bacterial and fungal strains. The compounds 4i, 4k and 4l has found comparatively good active against all the bacterial strains.

A highly functionalized heterocyclic compounds series were synthesized, characterized and tested for biological evaluation against bacteria and fungus. This novel synthetic route involves Schiff base formation reaction of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde with 4-(4-aminophenyl)morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. All the synthesized compounds were characterized using IR, 1H NMR and mass spectroscopic techniques. All the compound screened for antimicrobial activity against standard drugs.