Bone morphogenetic protein-2 enhanced local bone formation in the rabbit maxillary sinus model following implantation using a PBM carrier.

The aim of this study was to characterize the healing process of extraction sockets with a periapical lesion following immediate graft with collagenated bovine bone mineral (CBBM) soaked with epigallocatechin-3-gallate (EGCG). Following induction of periapical lesions in premolars in five dogs, treatment of extraction sockets was divided into three groups: control (no treatment) and two test groups, CBBM with or without EGCG. 3D reconstruction and superimposition of the digital images were used to measure the dimensional changes in alveolar ridge. Histologic specimen was evaluated in all groups. The horizontal ridge widths at 4-mm level were wider in both test groups (3.3 ± 1.7 mm in CBBM; 3.0 ± 1.7 mm in CBBM+EGCG) than in the control group (1.7 ± 2.4 mm). Fibrosis and limited new bone formation were observed in the apical regions of test groups; however, the extent of fibrosis was less in the CBBM+EGCG group. Within the limitations of this study, it was conjectured that adjunctive use of EGCG with CBBM can be a candidate biomaterial in grafting of extraction socket with periapical lesion. Bone regeneration at the coronal region of the CBBM grafted socket might not be influenced by the presence of a periapical lesion.

Purpose: The aim of this study was to evaluated biphasic calcium phosphate applied in surgically created 1-wall periodontal intrabony defects in dogs by histometrical analysis. Material and Method: Critical sized(4 mm × 4 mm), one wall periodontal intrabony defects were surgically produced at the proximal aspect of mandibular premolars in either right and left jaw quadrants in four canines. The control group was treated with debridement alone, and experimental group was treated with debridement and biphasic calcium phosphate application. The healing processes were histologically and histometrically observed after 8 weeks. Results: In biphasic calcium phosphate group, more new bone and cementum formation, less epithelium and connective tissue attachment were observed compared to other groups. But there was no statistical significance. Conclusion: Though the statistically significant difference could not be found, it seemed that there was more new bone and cementum formation with applying biphasic calcium phosphate in 1 wall intrabony defects in dogs by preventing junctional epithelium migration. (J Korean Acad Periodontol 2008;38:171-178) KEY WORDS: biphasic calcium phosphate, alloplastic materials, 1-wall defect.

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