human steady-state skin. Interestingly, although during lo-@@@@@@@@@@@@@@@@@ not required for monocyte recruitment or differentiation-tolerogenic functions, and maintained a tolerogenic nucle-@@@@@@@@@@@@@@@@@@@ @@@@@@@@@@@@@@@@@@-@@@@@@@@@@@@@@@@-lograft damage due to either innate-mediated ischemia-@@@@@@@@@@@@@@@@ Dr. Kupiec-Weglinski is director of the Dumont-UCLA Transplantation Gomez de Agüero M, Vocanson M, Hacini-Rachinel F, Taillardet M, Sparwasser T, Kissenpfennig A, et al. Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. J Clin Invest 2012; 122: 1700-1711. Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, Leboeuf M, et al. Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. Immunity 2012; 37: 1050-1060. Seneschal J, Clark RA, Gehad A, Baecher-Allan CM, Kupper TS. Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity 2012; 36: 873-884.

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Coronavirus disease (COVID-19) has infected more than 50 million people and killed more than one million, worldwide, during less than a year course. COVID-19, which has already become the worst pandemic in the last 100 years, is still spreading worldwide. Since the beginning of the outbreak, it has been of particular interest to understand whether COVID-19 is seasonal; the finding might help for better planning and preparation for the fight against the disease. Over the past 12 months, numerous empirical and epidemiological studies have been performed to define the distinct diffusion patterns of COVID-19. Thereby, a wealth of data has accumulated on the relationship between various seasonal meteorological factors and COVID-19 transmissibility at global and local scales. In this review, we aimed to discuss whether COVID-19 exhibits any seasonal features in a global and local perspective by collecting and providing summaries of the findings from empirical and epidemiological studies on the COVID-19 pandemic during its first seasonal cycle.