Diketo-1,3-dioxin-2-ones underwent retro-Diels-Alder reaction on heating in toluene at 110 degrees C to generate alpha,gamma,-triketo-ketenes. These were trapped with alcohols to provide 2,4,6-triketocarboxylates, which were smoothly aromatized by sequential reaction with potassium carbonate and methanolic hydrogen chloride to give resorcylate esters. The reaction was applied in the total synthesis of the marine antifungal agents 15G256beta (1), 15G256iota (2), and 15G256pi (3) and the mycotoxin S-(-)-zearalenone (4).

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CST (Crude Sulfate Turpentine) is an upcycled, biomass raw material derived from pinewood, obtained as a by-product of the Kraft process from the pulp and paper industry. The current article provides an overview of major renewable perfumery ingredients obtained from CST-derived alpha- and beta-pinene to-date and part of the Firmenich manufacturing portfolio, post DRT acquisition.

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