Fungi of Pleurotus genus have attracted a great interest due to their medicinal properties such as antiinflammatory, antimicrobial and antitumor. These properties are attributed mainly to polysaccharides synthesized by Pleurotus. This work aimed to study the mycelial growth of P. ostreatus in submerged culture, evaluating the influence of the initial concentration of substrate (20 and 40 g/L of glucose) and the pH (4 and 6) on kinetic parameters of production of biomass. The effectiveness of different doses (10, 30 and 50 mg/kg) of a mycelium polysaccharide fraction extracted from P. ostreatus in reducing Sarcoma 180 development in mice was also verified. In the range of this study, maximum concentration of mycelial biomass (about 12.8 g/L) was obtained using 40.0 g/L of glucose, at pH 4.0. The total biomass productivity (Px) was not significantly affected by substrate concentration and pH, reaching values of 0.034 g/L.h. Sarcoma 180 tumor weight was reduced in 74.1, 75.5 and 53.7% when 10, 30 and 50 mg/kg were administered, respectively. These results show the high antitumor potential of intracellular polysaccharide fraction of mycelial biomass of P. ostreatus, particularly at lower doses of 10 and 30 mg/kg.
A preocupação com os livros didáticos em nível oficial, no Brasil, se inicia com a Legislação do Livro Didático, criada em 1938 pelo Decreto-Lei 1006. Nesse período já o livro era considerado uma ferramenta da educação política e ideológica, sendo caracterizado o Estado como censor no uso desse material didático. A relação entre o livro didático e a Educação Ambiental é o envolvimento por diversas concepções que são expressas por distintas correntes do pensamento ambientalista. Essas correntes influenciam a forma de exercer a Educação Ambiental no âmbito escolar, assim como a seleção de conteúdos e a abordagem dos mesmos em sala de aula. O presente trabalho esboça a análise de alguns aspectos do Livro Didático de Ciências do ensino fundamental, 6º e 7º anos utilizados nas escolas públicas e particulares do município de Jaraguá do Sul - SC, bem como a aplicabilidade do tema Educação Ambiental, em diversas abordagens e metodologias ao ensino de Ciências.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.